Given these limitations in individual studies, it is similarly challenging to draw definitive broad conclusions about the pathogenesis, epidemiology, prevention and management of post-COVID conditions based on data across different studies. This includes difficulty identifying patients with post-COVID conditions in a consistent and systematic fashion and defining appropriate “control” populations for comparison. A separate definition may be applicable for children.” Key LiteratureĪs noted previously, all-encompassing standardized definitions of post-COVID conditions remain elusive, which means studies of patients at risk for or experiencing post-COVID symptoms have important methodologic and analytic limitations. Symptoms may also fluctuate or relapse over time. Symptoms may be new onset, following initial recovery from an acute COVID-19 episode, or persist from the initial illness. Common symptoms include fatigue, shortness of breath, cognitive dysfunction but also others which generally have an impact on everyday functioning. “Post COVID-19 condition occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, usually 3 months from the onset of COVID-19 with symptoms that last for at least 2 months and cannot be explained by an alternative diagnosis. In 2021, the World Health Organization published a working clinical case definition of post-COVID conditions that was developed by Delphi consensus (an iterative survey of experts, patients and other stakeholders designed to create a consensus definition): Centers for Disease Control and Prevention uses the umbrella term “ post-COVID conditions” to capture health problems that occur 4 or more weeks after acute COVID-19 infection.īecause of the wide variety of symptoms that may be encompassed by post-COVID conditions, and the lack of a definitive diagnostic test, standardized case definitions have been challenging to develop. These symptoms are referred to by many different names, including “long COVID,” “long-haul COVID,” “chronic COVID,” “post-COVID syndrome” and “post-acute COVID-19 syndrome,” as well as the research term “post-acute sequelae of SARS-CoV-2 infection (PASC).” The U.S. Some patients experience new, recurring or ongoing symptoms related to COVID-19 several weeks after the acute phase of infection ( Nalbandian, March 2021 Hope, June 2022). It is not comprehensive of all data related to this subject. The following is a curated review of key information and literature about this topic.
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